In fact, for over 15 years I played Runescape without ever using a bot of any kind (not an auto clicker or even any keybinds).
I’d like to start off by saying that I’ve never been a fan of using “bots” to play games for you – it defeats the purpose (to “play”) and can easily ruin online game communities (as was the case for many years in Runescape before the bot crackdown). How to Write a Runescape Auto Clicker with Python, Part I